tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

Base Information

Chemical Name:tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate
CAS No.:1383377-68-1
Molecular Formula:C₂₄H₂₆FN₅O₃
Molecular Weight:451.501
Hs Code.:

Synonyms:tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

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Chemical Property of tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

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Technology Process of tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

There total 8 articles about tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383377-67-0
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

: 95656-86-3,119768-44-4,138457-45-1
tert-butyl 2-hydroxypropylcarbamate

: 1383377-68-1
tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; at 0 - 20 ℃; for 3h;

Reference yield:

: 399-88-2
3-fluoro-4-methylpyridine

: 1383377-68-1
tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 5 °C

1.2: 0 - 20 °C

2.1: tetrahydrofuran / 3 h / 80 - 100 °C

3.1: ethanol / 0 - 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

5.1: triethylamine / acetonitrile / 96 h / 70 °C

6.1: 2-(methylsulfonyl)ethyl alcohol; sodium hydride / tetrahydrofuran / 18 h / 0 - 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / 3 h / 0 - 20 °C

With 2-(methylsulfonyl)ethyl alcohol; di-isopropyl azodicarboxylate; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383377-68-1
tert-butyl 2-(2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridin-3-yloxy)propylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2: 2-(methylsulfonyl)ethyl alcohol; sodium hydride / tetrahydrofuran / 18 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / 3 h / 0 - 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2-(methylsulfonyl)ethyl alcohol; di-isopropyl azodicarboxylate; sodium hydride; caesium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;