4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

Base Information

Chemical Name:4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile
CAS No.:1383377-67-0
Molecular Formula:C₁₆H₁₁FN₄O
Molecular Weight:294.288
Hs Code.:

Synonyms:4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

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Chemical Property of 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

Chemical Property:

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Technology Process of 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

There total 7 articles about 4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

: 1383377-67-0
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

Guidance literature:: With 2-(methylsulfonyl)ethyl alcohol; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

Reference yield:

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383377-67-0
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2: 2-(methylsulfonyl)ethyl alcohol; sodium hydride / tetrahydrofuran / 18 h / 0 - 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2-(methylsulfonyl)ethyl alcohol; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1383377-58-9
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)pyridine 1-oxide

: 1383377-67-0
4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-3-hydroxypicolinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 96 h / 70 °C

2: 2-(methylsulfonyl)ethyl alcohol; sodium hydride / tetrahydrofuran / 18 h / 0 - 20 °C

With 2-(methylsulfonyl)ethyl alcohol; sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;