Forapin

Base Information

Chemical Name:Forapin
CAS No.:20449-79-0
Molecular Formula:C131H229N39O31
Molecular Weight:2846.5
Hs Code.:2934999090
European Community (EC) Number:253-417-7,629-303-1
ChEMBL ID:CHEMBL412927
DSSTox Substance ID:DTXSID001046261
Metabolomics Workbench ID:133842
Wikidata:Q424512
Wikipedia:Melittin
Mol file:20449-79-0.mol

Synonyms:Melitten;Melittin;Mellitin

Suppliers and Price of Forapin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Melittin
500ug
$ 403.00

Usbiological
Melittin
10mg
$ 360.00

Usbiological
Melittin
1mg
$ 332.00

Usbiological
Melittin
1mg
$ 531.00

Usbiological
Melittin
1mg
$ 515.00

TRC
Melittin
5mg
$ 1570.00

Tocris
Melittin
500U
$ 162.00

Sigma-Aldrich
Melittin ≥97% (HPLC), synthetic
1mg
$ 1350.00

Sigma-Aldrich
Melittin from honey bee venom ≥85% (HPLC)
25mg
$ 792.00

Sigma-Aldrich
Melittin ≥97% (HPLC), synthetic
250 μg
$ 415.00

Total 124 raw suppliers

Chemical Property of Forapin

Chemical Property:

PSA：1152.34000
Density:1.39
LogP:7.51980
Storage Temp.:2-8°C
XLogP3:-2.7
Hydrogen Bond Donor Count:41
Hydrogen Bond Acceptor Count:37
Rotatable Bond Count:99
Exact Mass:2845.7575265
Heavy Atom Count:201
Complexity:6300

Purity/Quality:

99%, ^*data from raw suppliers

Melittin ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 23/24/25
Safety Statements: 36-45-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)N)NC(=O)CN
Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N)NC(=O)CN
Uses Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions. Melittin from honey bee venom has been used:In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Technology Process of Forapin

There total 1 articles about Forapin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 68858-20-8
Fmoc-Val-OH

: 35661-60-0
Fmoc-Leu-OH

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 71989-31-6
Fmoc-Pro-OH

: 71989-23-6,251316-98-0
Fmoc-Ile-OH

: 35737-15-6
Fmoc-Trp-OH

: 73731-37-0
Fmoc-Thr-OH

: 105047-45-8
Fmoc-Lys-OH

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

: 71989-20-3
N₂-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine

: 91000-69-0,130752-32-8
Fmoc-L-Arg-OH

: 20449-79-0
melittin from honey bee venom

Guidance literature:: N₂-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine; With 1-hydroxy-7-aza-benzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

With piperidine; In N,N-dimethyl-formamide; for 0.55h;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; Fmoc-Ile-OH; Fmoc-Trp-OH; Fmoc-Thr-OH; Fmoc-Lys-OH; N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine; Fmoc-L-Arg-OH; Further stages;
DOI:10.1021/acs.biomac.5b00163

Reference yield:

: 20449-79-0
melittin from honey bee venom

: 2,3,5,6-tetrafluorophenyl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

: ethyl 4-(4-(formyloxy)phenoxy)butanoate

: 137215-27-1
7-mercapto-4-methyl-2H-chromen-2-one

: C₁₃₂H₂₃₀N₄₀O₃₂

: 143216-03-9
4-(4-ethoxy-4-oxobutoxy)benzoic acid

: 166954-96-7
4-(4-hydroxy-phenoxy)-butyric acid ethyl ester

Guidance literature:: melittin from honey bee venom; ethyl 4-(4-(formyloxy)phenoxy)butanoate; In aq. phosphate buffer; dimethyl sulfoxide; at 25 ℃; for 3h; pH=7.0;

2,3,5,6-tetrafluorophenyl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate; In aq. phosphate buffer; dimethyl sulfoxide; for 0.25h; pH=7.0;

7-mercapto-4-methyl-2H-chromen-2-one; In aq. phosphate buffer; dimethyl sulfoxide;
DOI:10.1039/c6cc09555k