CAS No.20449-79-0,Melittin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	20449-79-0
Name:	Melittin

Formula:	C₁₃₁H₂₂₉N₃₉O₃₁
Molecular Weight:	2846.5
Synonyms:	Melittin (apis cerana);Melittin (honeybee);Honeybee melittin;Bee venom melittin;Forapin;Melittin I;Melitten;11030-50-5;Forapine;glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-Lthreonyl-L-threonylglycyl-L-leucyl-Lprolyl-L-alanyl-L-leucyl-L-isoleucyl-Lseryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-Lglutaminyl-;L-Glutamamide, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-Leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-;Melittin (major);Melittin (major) (8CI);
EINECS:	253-417-7
Density:	1.39
Hazard Symbols:	T
Risk Codes:	23/24/25
Safety:	36-45-36/37/39
Transport Information:	UN 3462 6.1/PG 1
PSA:	1152.34000
LogP:	7.51980

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Chemistry

Product Name: Melitten
Molecular formula: C₁₃₁H₂₂₉N₃₉O₃₁
Molar mass: 2846.46266
XLogP3-AA: -2.7
H-Bond Donor: 41
H-Bond Acceptor: 41
Rotatable Bond Count: 99
Tautomer Count: 1000
Exact Mass: 2905.127855
MonoIsotopic Mass: 2844.754172
Topological Polar Surface Area: 1150
Heavy Atom Count: 201
storage temp. of Melitten (CAS NO.20449-79-0): 2-8 °C

Uses

Melitten (CAS NO.20449-79-0) also exhibits potent anti-microbial activity. For example, Melittin has been shown to exert "profound inhibitory effects" on Borrelia burgdorferi, the bacteria that causes lyme disease. Melittin has also been shown to kill the yeast Candida albicans and to suppress Mycoplasma hominis and Chlamydia trachomatis infections. At Washington University School of Medicine in St. Louis, very small nanite "nanobee" devices are being used to carefully deliver melittin, which is known to disrupt cellular walls and thus destroy cells, to tumor cells.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	intraperitoneal	2750ug/kg (2.75mg/kg)	Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974.
mouse	LD50	intraperitoneal	7400ug/kg (7.4mg/kg)	Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974.
mouse	LD50	intravenous	7040ug/kg (7.04mg/kg)	Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974.
rat	LD50	intraperitoneal	17700ug/kg (17.7mg/kg)	Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974.
rat	LDLo	intravenous	1400ug/kg (1.4mg/kg)	Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974.

Safety Profile

Hazard Codes: Toxic T
Risk Statements: 23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 36-45-36/37/39
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 3462 6.1/PG 1
WGK Germany; 3
RTECS: OS3965000

Specification

Melitten (CAS NO.20449-79-0), its Synonyms are Bee venom melittin ; Forapin ; Forapine ; Honeybee melittin ; L-Glutamamide, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-Leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl- ; Melittin (apis cerana) ; Melittin I .