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| CAS No.: | 20449-79-0 |
|---|---|
| Name: | Melittin |
| Molecular Structure: | |
|
|
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| Formula: | C131H229N39O31 |
| Molecular Weight: | 2846.5 |
| Synonyms: | Melittin (apis cerana);Melittin (honeybee);Honeybee melittin;Bee venom melittin;Forapin;Melittin I;Melitten;11030-50-5;Forapine;glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-Lthreonyl-L-threonylglycyl-L-leucyl-Lprolyl-L-alanyl-L-leucyl-L-isoleucyl-Lseryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-Lglutaminyl-;L-Glutamamide, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-Leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-;Melittin (major);Melittin (major) (8CI); |
| EINECS: | 253-417-7 |
| Density: | 1.39 |
| Hazard Symbols: |
 T
|
| Risk Codes: | 23/24/25 |
| Safety: | 36-45-36/37/39 |
| Transport Information: | UN 3462 6.1/PG 1 |
| PSA: | 1152.34000 |
| LogP: | 7.51980 |
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Chemistry
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Product Name: Melitten
Molecular formula: C131H229N39O31
Molar mass: 2846.46266
XLogP3-AA: -2.7
H-Bond Donor: 41
H-Bond Acceptor: 41
Rotatable Bond Count: 99
Tautomer Count: 1000
Exact Mass: 2905.127855
MonoIsotopic Mass: 2844.754172
Topological Polar Surface Area: 1150
Heavy Atom Count: 201
storage temp. of Melitten (CAS NO.20449-79-0): 2-8 °C
Uses
Melitten (CAS NO.20449-79-0) also exhibits potent anti-microbial activity. For example, Melittin has been shown to exert "profound inhibitory effects" on Borrelia burgdorferi, the bacteria that causes lyme disease. Melittin has also been shown to kill the yeast Candida albicans and to suppress Mycoplasma hominis and Chlamydia trachomatis infections. At Washington University School of Medicine in St. Louis, very small nanite "nanobee" devices are being used to carefully deliver melittin, which is known to disrupt cellular walls and thus destroy cells, to tumor cells.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 2750ug/kg (2.75mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| mouse | LD50 | intraperitoneal | 7400ug/kg (7.4mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| mouse | LD50 | intravenous | 7040ug/kg (7.04mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| rat | LD50 | intraperitoneal | 17700ug/kg (17.7mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. | |
| rat | LDLo | intravenous | 1400ug/kg (1.4mg/kg) | Farmakologiya i Toksikologiya Vol. 37, Pg. 367, 1974. |
Safety Profile
Hazard Codes: 
T
Risk Statements: 23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 36-45-36/37/39
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 3462 6.1/PG 1
WGK Germany; 3
RTECS: OS3965000
Specification
Melitten (CAS NO.20449-79-0), its Synonyms are Bee venom melittin ; Forapin ; Forapine ; Honeybee melittin ; L-Glutamamide, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-Leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl- ; Melittin (apis cerana) ; Melittin I .