4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

Base Information

Chemical Name:4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one
CAS No.:1312954-63-4
Molecular Formula:C₁₂H₁₁ClFN₃OS
Molecular Weight:299.756
Hs Code.:

Synonyms:4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

Chemical Property:

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Technology Process of 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

There total 8 articles about 4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312954-62-3
4-(2-chloro-5-fluorobenzyl)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one

: 74-88-4
methyl iodide

: 1312954-63-4
4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 0.666667h;

Reference yield:

: 2252-50-8
2-chloro-5-fluoro-benzoic acid

: 1312954-63-4
4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 24 h / Reflux

2: sodium tetrahydroborate; methanol / 1 h / 20 °C

3: phosphorus tribromide / 1,2-dimethoxyethane / 3 h / 0 - 20 °C

4: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

5: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

6: sulfuric acid / methanol / 15 h / Reflux

7: sodium methylate / methanol / 36 h / Reflux

8: sodium hydroxide / ethanol / 0.67 h / 20 °C

With methanol; sodium tetrahydroborate; hydrazine hydrate; sulfuric acid; sodium methylate; phosphorus tribromide; sodium iodide; sodium hydroxide; sulfuric acid; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 81778-09-8
1-(bromomethyl)-2-chloro-5-fluorobenzene

: 1312954-63-4
4-(2-chloro-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

2: hydrazine hydrate / 1,4-dioxane / 2 h / 0 - 20 °C

3: sulfuric acid / methanol / 15 h / Reflux

4: sodium methylate / methanol / 36 h / Reflux

5: sodium hydroxide / ethanol / 0.67 h / 20 °C

With hydrazine hydrate; sodium methylate; sodium iodide; sodium hydroxide; sulfuric acid; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;