2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole

Base Information

• Chemical Name: 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole
• CAS No.: 1258428-53-3
• Molecular Formula: C₂₁H₂₃NO
• Molecular Weight: 305.42
• Mol file: 1258428-53-3.mol

Synonyms:2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole

Chemical Property of 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole

Chemical Property:

Purity/Quality:

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Technology Process of 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole

There total 1 articles about 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-[4-(i-propyl)phenyl]-pentane-1,4-dione (1033280-93-1) + 4-methoxy-aniline (104-94-9) → 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole (1258428-53-3)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 160 ℃; for 0.5h; under 7757.43 Torr; Microwave irradiation;

DOI:10.1016/j.bmc.2010.09.006

Reference yield: 40.0%

Thiomorpholin (123-90-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole (1258428-53-3) → 2-methyl-3-[(thiomorpholin-4-yl)-methyl]-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole (1258428-30-6)

Guidance literature:

Thiomorpholin; formaldehyd; 2-methyl-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole; With acetic acid; In water; acetonitrile; at 20 ℃; for 1h;

With sodium hydroxide; In water; acetonitrile;

DOI:10.1016/j.bmc.2010.09.006

upstream raw materials:

1-[4-(i-propyl)phenyl]-pentane-1,4-dione

4-methoxy-aniline

Downstream raw materials:

2-methyl-3-[(thiomorpholin-4-yl)-methyl]-5-[4-(i-propyl)phenyl]-1-[4-(methoxy)phenyl]-1H-pyrrole