(2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate
CAS No.:1572937-40-6
Molecular Formula:C₂₃H₂₇FN₂O₆
Molecular Weight:446.476
Hs Code.:

Synonyms:(2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

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Chemical Property of (2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

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Technology Process of (2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

There total 4 articles about (2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1572937-33-7
(2S,4R)-tert-butyl 2-(hydroxymethyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 1572937-40-6
(2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

Guidance literature:: With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1572937-40-6
(2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

2: lithium borohydride / tetrahydrofuran

3: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0 °C

With lithium borohydride; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: |Mitsunobu Displacement;

Reference yield:

: 1572937-32-6
(2S,4R)-1-tert-butyl 2-methyl 4-(3-nitrophenoxy)pyrrolidine-1,2-dicarboxylate

: 1572937-40-6
(2S,4R)-tert-butyl 2-(((3-fluorobenzyl)oxy)methyl)-4-(3-nitrophenoxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran

2: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0 °C

With lithium borohydride; sodium hydride; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;