tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

Base Information

Chemical Name:tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate
CAS No.:1621514-21-3
Molecular Formula:C₂₈H₃₃N₃O₈
Molecular Weight:539.585
Hs Code.:

Synonyms:tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

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Chemical Property of tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

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Technology Process of tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

There total 5 articles about tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1621513-92-5
tert-butyl 2-(4-(5-(1-hydroxypropyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

: 63289-53-2
4-nitrobenzyl isocyanate

: 1621514-21-3
tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

Guidance literature:: With pyridine; copper(l) chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201310618

Reference yield:

: 343322-79-2
tert-butyl 2-(4-formylphenoxy)-2-methylpropanoate

: 1621514-21-3
tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 12 h / 65 °C / Inert atmosphere

2: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

3: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium carbonate; triethylamine; copper(l) chloride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/anie.201310618

Reference yield:

: 1621513-91-4
tert-butyl 2-(4-((hydroxyimino)methyl)phenoxy)-2-methylpropanoate

: 1621514-21-3
tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

2: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; triethylamine; copper(l) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201310618