1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Base Information

Chemical Name:1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate
CAS No.:1621514-25-7
Molecular Formula:C₂₇H₂₈N₆O₅
Molecular Weight:516.557
Hs Code.:

Synonyms:1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Suppliers and Price of 1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

There total 7 articles about 1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1621514-23-5
tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

: 2450-71-7
Propargylamine

: 1621514-25-7
1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201310618

Reference yield:

: 343322-79-2
tert-butyl 2-(4-formylphenoxy)-2-methylpropanoate

: 1621514-25-7
1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 12 h / 65 °C / Inert atmosphere

2: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

3: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 20 °C / Inert atmosphere

5: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 1 h / 20 °C / Inert atmosphere

6: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; tert.-butylnitrite; trimethylsilylazide; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/anie.201310618

Reference yield:

: 1621514-21-3
tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

: 1621514-25-7
1-(3-(4-((2-methyl-1-oxo-1-(prop-2-yn-1-ylamino)propan-2-yl)oxy)phenyl)isoxazol-5-yl)propyl 4-azidobenzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 20 °C / Inert atmosphere

2: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 1 h / 20 °C / Inert atmosphere

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 1,4-dioxane / 12 h / 20 °C / Inert atmosphere

With tert.-butylnitrite; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1002/anie.201310618