tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

Base Information

Chemical Name:tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate
CAS No.:1621514-23-5
Molecular Formula:C₂₈H₃₃N₅O₆
Molecular Weight:535.6
Hs Code.:

Synonyms:tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

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Chemical Property of tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

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Technology Process of tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

There total 7 articles about tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1621514-22-4
tert-butyl 2-(4-(5-(1-(((4-aminobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

: 1621514-23-5
tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

Guidance literature:: With tert.-butylnitrite; trimethylsilylazide; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201310618

Reference yield:

: 343322-79-2
tert-butyl 2-(4-formylphenoxy)-2-methylpropanoate

: 1621514-23-5
tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 12 h / 65 °C / Inert atmosphere

2: N-chloro-succinimide; pyridine; triethylamine / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

3: pyridine; copper(l) chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 20 °C / Inert atmosphere

5: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 1 h / 20 °C / Inert atmosphere

With pyridine; N-chloro-succinimide; tert.-butylnitrite; trimethylsilylazide; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium carbonate; triethylamine; copper(l) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1002/anie.201310618

Reference yield:

: 1621514-21-3
tert-butyl 2-methyl-2-(4-(5-(1-(((4-nitrobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)propanoate

: 1621514-23-5
tert-butyl 2-(4-(5-(1-(((4-azidobenzyl)carbamoyl)oxy)propyl)isoxazol-3-yl)phenoxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 20 °C / Inert atmosphere

2: tert.-butylnitrite; trimethylsilylazide / acetonitrile / 1 h / 20 °C / Inert atmosphere

With tert.-butylnitrite; trimethylsilylazide; palladium 10% on activated carbon; hydrogen; In methanol; acetonitrile;
DOI:10.1002/anie.201310618