2-Fluoro-2-propen-1-ol

Base Information

• Chemical Name: 2-Fluoro-2-propen-1-ol
• CAS No.: 5675-31-0
• Molecular Formula: C3H5FO
• Molecular Weight: 76.0705
• Hs Code.: 2905299090
• European Community (EC) Number: 805-652-7
• UNII: JF81WO4HV7
• DSSTox Substance ID: DTXSID70205308
• Nikkaji Number: J51.041F
• Wikidata: Q27281486
• Mol file: 5675-31-0.mol

Synonyms:2-Fluoro-2-propen-1-ol;2-fluoroprop-2-en-1-ol;5675-31-0;2-Fluoroallyl alcohol;2-Propen-1-ol, 2-fluoro-;BRN 1901072;UNII-JF81WO4HV7;JF81WO4HV7;2-fluoro-prop-2-en-1-ol;DTXSID70205308;MFCD01696257;AKOS024263086;LS-123786;EN300-395971;Q27281486

Chemical Property of 2-Fluoro-2-propen-1-ol

Chemical Property:

• Vapor Pressure: 110mmHg at 25°C
• Boiling Point: 66.8°C at 760 mmHg
• PKA: 13.47±0.10(Predicted)
• Flash Point: 25°C
• PSA: 20.23000
• Density: 1.002g/cm³
• LogP: 0.46190
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 76.032442941
• Heavy Atom Count: 5
• Complexity: 42.2

Purity/Quality:

2-FluoroallylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=C(CO)F

Technology Process of 2-Fluoro-2-propen-1-ol

There total 1 articles about 2-Fluoro-2-propen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-2-ethoxy-1-fluorocyclopropane (75681-85-5) → ethanol (64-17-5) + 2-fluoro-2-propen-1-ol (5675-31-0)

Guidance literature:

With sodium tetrahydroborate; sodium dodecyl-sulfate; dihydroquinine; Yield given. Multistep reaction. Title compound not separated from byproducts; 1) reflux then distillation, 2) 16 h;

DOI:10.1002/hlca.19800630517

Reference yield: 90.0%

2-fluoro-2-propen-1-ol (5675-31-0) + p-toluenesulfonyl chloride (98-59-9) → 2-fluoroallyl 4-methylbenzenesulfonate

Guidance literature:

With sodium hydroxide; In diethyl ether;

DOI:10.1021/jm8015014

Reference yield: 86.0%

2-fluoro-2-propen-1-ol (5675-31-0) + 4-methoxy-benzoyl chloride (100-07-2) → 2-fluoroallyl 4-methoxybenzoate

Guidance literature:

With pyridine; at 0 - 24 ℃; for 24.5h;

DOI:10.1021/acs.joc.6b01709

upstream raw materials:

1-chloro-2-ethoxy-1-fluorocyclopropane

Downstream raw materials:

chloromethylphosphonic acid

2-fluoroprop-2-enyl 2-(benzoylamino)propanoate

α-fluoroacrolein

2-fluoroallyl (4-methoxyphenyl)carbamate