N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

Base Information

Chemical Name:N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide
CAS No.:1352721-45-9
Molecular Formula:C₂₁H₂₅N₅O
Molecular Weight:363.462
Hs Code.:

Synonyms:N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

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Chemical Property of N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

Chemical Property:

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Technology Process of N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

There total 9 articles about N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352721-46-0
N-{2-[4-(2-amino-phenylamino)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

: 1352721-45-9
N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

Guidance literature:: With bromocyane; water; In acetonitrile; at 20 ℃; for 23h;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1352721-45-9
N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / acetonitrile / 20 h / 20 - 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 °C / 760.05 Torr

3: triethylamine / ethyl acetate / 1 h / 80 °C

4: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.25 h / 150 °C / Sealed vessel

6: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 760.05 Torr

7: water; bromocyane / acetonitrile / 23 h / 20 °C

With bromocyane; water; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352721-45-9
N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.25 h / 150 °C / Sealed vessel

2: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 760.05 Torr

3: water; bromocyane / acetonitrile / 23 h / 20 °C

With bromocyane; water; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; acetonitrile;