N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

Base Information

Chemical Name:N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide
CAS No.:1352720-96-7
Molecular Formula:C₃₀H₃₂N₆O
Molecular Weight:492.624
Hs Code.:

Synonyms:N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

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Chemical Property of N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

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Technology Process of N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

There total 13 articles about N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1352721-45-9
N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide

: 220499-13-8
tert-butyl 4-(bromomethyl)-1H-1-indolecarboxylate

: 1352720-96-7
N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

Guidance literature:: N-{2-[4-(2-amino-benzoimidazol-1-yl)-piperidin-1-yl]-4-methyl-phenyl}-acetamide; tert-butyl 4-(bromomethyl)-1H-1-indolecarboxylate; With potassium iodide; In acetonitrile; at 110 ℃; for 0.5h; Sealed vial;

With trifluoroacetic acid;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1352720-96-7
N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: caesium carbonate / acetonitrile / 20 h / 20 - 50 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1.5 h / 20 °C / 760.05 Torr

3: triethylamine / ethyl acetate / 1 h / 80 °C

4: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.25 h / 150 °C / Sealed vessel

6: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 760.05 Torr

7: water; bromocyane / acetonitrile / 23 h / 20 °C

8: potassium iodide / acetonitrile / 0.5 h / 110 °C / Sealed vial

With bromocyane; water; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352720-96-7
N-(2-{4-[2-imino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-piperidin-1-yl}-4-methyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2.25 h / 150 °C / Sealed vessel

2: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 760.05 Torr

3: water; bromocyane / acetonitrile / 23 h / 20 °C

4: potassium iodide / acetonitrile / 0.5 h / 110 °C / Sealed vial

With bromocyane; water; hydrogen; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium 10% on activated carbon; In methanol; acetonitrile;