Technology Process of N-(1-cyclohexylmethyl-allyl)-3-phenyl-propionamide
There total 4 articles about N-(1-cyclohexylmethyl-allyl)-3-phenyl-propionamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-Phenylpropionic acid;
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
at 0 ℃;
for 0.5h;
With
pyridine; 4-hydroxy-3-nitrobenzophenone resin;
In
dichloromethane;
for 10h;
(S)-1-Cyclohexylmethyl-allylamine;
In
dichloromethane;
for 24h;
Further stages.;
DOI:10.1021/ol0166496
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Ti(OEt)4 / CH2Cl2; propan-2-ol / 20 °C
2.1: Mg / I2 / diethyl ether / Heating
2.2: diethyl ether; CH2Cl2 / 20 h / -48 - 20 °C
3.1: dioxane; methanol / 0.5 h
4.1: dicyclohexylcarbodiimide / CH2Cl2 / 0.5 h / 0 °C
4.2: 4-hydroxy-3-nitrobenzophenone resin; pyridine / CH2Cl2 / 10 h
4.3: 100 percent / CH2Cl2 / 24 h
With
titanium(IV) tetraethanolate; magnesium; dicyclohexyl-carbodiimide;
iodine;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol0166496
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Mg / I2 / diethyl ether / Heating
1.2: diethyl ether; CH2Cl2 / 20 h / -48 - 20 °C
2.1: dioxane; methanol / 0.5 h
3.1: dicyclohexylcarbodiimide / CH2Cl2 / 0.5 h / 0 °C
3.2: 4-hydroxy-3-nitrobenzophenone resin; pyridine / CH2Cl2 / 10 h
3.3: 100 percent / CH2Cl2 / 24 h
With
magnesium; dicyclohexyl-carbodiimide;
iodine;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol0166496
