(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:339178-43-7
Molecular Formula:C₂₆H₃₂N₂O₅Si
Molecular Weight:480.636
Hs Code.:

Synonyms:(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of (2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of (2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 6 articles about (2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 339178-42-6
(2R,4R,5R)-1-[5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-(tert-butyldiphenylsilanyloxy)tetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 339178-43-7
(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With Amberlyst 15-H; In methanol; at 20 ℃; for 37h;
DOI:10.1021/jo001223a

Reference yield:

: 124680-51-9
(2R,4R,5R)-1-[5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 339178-43-7
(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / imidazole / dimethylformamide / 1.5 h / Heating

2: 100 percent / Amberlyst 15-H / methanol / 37 h / 20 °C

With 1H-imidazole; Amberlyst 15-H; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo001223a

Reference yield:

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

: 339178-43-7
(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / Py / 18 h / 0 °C

2: 91 percent / NaOH / ethanol; H₂O / 2 h / Heating

3: 100 percent / NaOH / ethanol; H₂O / 3 h / Heating

4: 94 percent / imidazole / dimethylformamide / 1.5 h / Heating

5: 100 percent / Amberlyst 15-H / methanol / 37 h / 20 °C

With pyridine; 1H-imidazole; sodium hydroxide; Amberlyst 15-H; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001223a