(2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

Base Information

Chemical Name:(2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid
CAS No.:339178-44-8
Molecular Formula:C₂₆H₃₀N₂O₆Si
Molecular Weight:494.62
Hs Code.:

Synonyms:(2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

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Chemical Property of (2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

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Technology Process of (2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

There total 7 articles about (2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 339178-43-7
(2R,4R,5R)-1-[4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 339178-44-8
(2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo001223a

Reference yield:

: 124680-51-9
(2R,4R,5R)-1-[5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 339178-44-8
(2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / imidazole / dimethylformamide / 1.5 h / Heating

2: 100 percent / Amberlyst 15-H / methanol / 37 h / 20 °C

3: 100 percent / 2,2,6,6-tetramethyl-1-piperidinyl-oxy; iodobenzene diacetate / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; Amberlyst 15-H; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo001223a

Reference yield:

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

: 339178-44-8
(2S,3R,5R)-3-(tert-butyldiphenylsilanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahydrofuran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Py / 18 h / 0 °C

2: 91 percent / NaOH / ethanol; H₂O / 2 h / Heating

3: 100 percent / NaOH / ethanol; H₂O / 3 h / Heating

4: 94 percent / imidazole / dimethylformamide / 1.5 h / Heating

5: 100 percent / Amberlyst 15-H / methanol / 37 h / 20 °C

6: 100 percent / 2,2,6,6-tetramethyl-1-piperidinyl-oxy; iodobenzene diacetate / CH₂Cl₂ / 2 h / 20 °C

With pyridine; 1H-imidazole; sodium hydroxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; Amberlyst 15-H; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001223a