tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane

Base Information

• Chemical Name: tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane
• CAS No.: 870074-98-9
• Molecular Formula: C₂₇H₄₉IO₃Si
• Molecular Weight: 576.674

Synonyms:tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane

Chemical Property of tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane

Chemical Property:

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Technology Process of tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane

There total 2 articles about tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,3R,4R,5S,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4,6-trimethyl-decan-1-ol (870075-17-5) → tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane (870074-98-9)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; benzene; at 20 ℃; for 1h;

DOI:10.1021/ol052070m

Reference yield:

(2S,3R,4R,5S,6S,Z)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyldeca-7,9-dien-1-ol (398518-64-4) → tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane (870074-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / PtO₂ / ethyl acetate / 1 h

2: 95 percent / PPh₃; imidazole; I₂ / benzene; diethyl ether / 1 h / 20 °C

With 1H-imidazole; hydrogen; iodine; triphenylphosphine; platinum(IV) oxide; In diethyl ether; ethyl acetate; benzene;

DOI:10.1021/ol052070m

Reference yield: 82.0%

tert-Butyl-((Z)-(2S,3R,4S)-6-iodo-3-methoxymethoxy-2,4-dimethyl-hept-5-enyloxy)-dimethyl-silane (852049-56-0) + tert-Butyl-[(1S,2R,3S,4S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2,4-dimethyl-octyloxy]-dimethyl-silane (870074-98-9) → 1-[(Z)-(1S,2R,3R,4S,8S,9R,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxymethoxy-2,4,6,8,10-pentamethyl-1-((S)-1-methyl-pentyl)-undec-6-enyloxymethyl]-4-methoxy-benzene (870075-18-6)

Guidance literature:

With caesium carbonate; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾;

DOI:10.1021/ol052070m

upstream raw materials:

(2S,3R,4R,5S,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4,6-trimethyl-decan-1-ol

(2S,3R,4R,5S,6S,Z)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6-trimethyldeca-7,9-dien-1-ol

Downstream raw materials:

1-[(Z)-(1S,2R,3R,4S,8S,9R,10S)-3,11-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxymethoxy-2,4,6,8,10-pentamethyl-1-((S)-1-methyl-pentyl)-undec-6-enyloxymethyl]-4-methoxy-benzene

(Z)-(2S,3R,4S,8S,9R,10R,11S,12S)-9-(tert-Butyl-dimethyl-silanyloxy)-11-(4-methoxy-benzyloxy)-3-methoxymethoxy-2,4,6,8,10,12-hexamethyl-hexadec-5-en-1-ol

(5R,6S)-6-[(3Z,8Z)-(2S,5S,6S,7S,11S,12R,13R,14S,15S)-2,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(4-methoxy-benzyloxy)-6-methoxymethoxy-5,7,9,11,13,15-hexamethyl-nonadeca-3,8-dienyl]-5-methyl-tetrahydro-pyran-2-one

(2R,3R,4S,5Z,8S,9R,10R,11S,12S,Z)-9-(tert-butyldimethylsilyloxy)-11-(4-methoxybenzyloxy)-3-(methoxymethyloxy)-2,4,6,8,10,12-hexamethylhexadec-5-enal

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