2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester
CAS No.:1446326-20-0
Molecular Formula:C₃₆H₅₆O₃Si
Molecular Weight:564.924
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

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Chemical Property of 2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

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Technology Process of 2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

There total 5 articles about 2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 2,2-dimethylpropionic acid 8-{(1R,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methyl-propyl]cyclopropyl}oct-7-enyl ester

: 1446326-20-0
2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

Guidance literature:: With trisylhydrazine; In tetrahydrofuran; at 40 - 50 ℃; for 41h;
DOI:10.1016/j.tet.2013.04.134

Reference yield:

: 918905-62-1
trans-(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropanecarbaldehyde

: 1446326-20-0
2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 20 h / -12 - 20 °C

2: trisylhydrazine / tetrahydrofuran / 41 h / 40 - 50 °C

With trisylhydrazine; lithium hexamethyldisilazane; In tetrahydrofuran; 1: |Julia-Kocienski Olefination;
DOI:10.1016/j.tet.2013.04.134

Reference yield:

: 1446326-24-4
7-bromoheptyl pivalate

: 1446326-20-0
2,2-dimethylpropionic acid 8-{(1S,2R)-2-[(S)-3-(tert-butyldiphenylsilanyloxy)-1-methylpropyl]cyclopropyl}octyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / Reflux

2: dihydrogen peroxide; ammonium molybdate tetrahydrate / 18.67 h / 15 - 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 20 h / -12 - 20 °C

4: trisylhydrazine / tetrahydrofuran / 41 h / 40 - 50 °C

With ammonium molybdate tetrahydrate; trisylhydrazine; dihydrogen peroxide; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; 3: |Julia-Kocienski Olefination;
DOI:10.1016/j.tet.2013.04.134