S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide

Base Information

• Chemical Name: S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide
• CAS No.: 1147095-67-7
• Molecular Formula: C₂₁H₁₈Cl₂N₄O₅S₂
• Molecular Weight: 541.436
• Mol file: 1147095-67-7.mol

Synonyms:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide

Chemical Property of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide

There total 12 articles about S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl sulfoximide (1147095-59-7,1147096-64-7) + methanesulfonyl chloride (124-63-0) → S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide (1147095-67-7)

Guidance literature:

With pyridine; In dichloromethane; at 10 - 30 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.10.005

Reference yield: 51.0%

→ S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide (1147095-67-7)

Guidance literature:

Reference yield:

methyl 4-(methylsulfinyl)benzoate (114129-35-0) → S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-methanesulfonyl sulfoximide (1147095-67-7)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium azide; sulfuric acid / chloroform / 15 h / -20 - 50 °C / Inert atmosphere

2: pyridine / dichloromethane; toluene / 3 h / 15 - 30 °C / Inert atmosphere

3: water; sodium hydroxide / tetrahydrofuran / 3 h / 25 - 30 °C

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

5: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

6: sulfuric acid / 0 - 5 °C

7: pyridine / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

With pyridine; sodium azide; oxalyl dichloride; sulfuric acid; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; toluene;

DOI:10.1016/j.ejmech.2012.10.005

upstream raw materials:

methyl 4-(methylsulfinyl)benzoate

5-chloro-2-nitrobenzoic acid

S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-benzyloxycarbonyl sulfoximide

methyl 4-[imino(methyl)oxo-λ⁶-sulfanyl]benzoate

Refernces

• 1、 -. "SULFOXIMINE DERIVATIVES AS FACTOR XA INHIBITORS". Page/Page column 13. . Retrieved 2011/04/18.