tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

Base Information

Chemical Name:tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate
CAS No.:102613-65-0
Molecular Formula:C₃₆H₄₄N₂O₁₂
Molecular Weight:696.752
Hs Code.:

tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'-<bis(methoxycarbonyl)methyl>-5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

Synonyms:tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

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Chemical Property of tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

There total 11 articles about tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 75975-52-9
3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 51912-05-1
5-acetoxymethyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester

: 102613-65-0
tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 40 ℃; for 5h;
DOI:10.1021/jo00365a028

Reference yield:

: 70988-56-6
t-butyl 4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylate

: 51912-05-1
5-acetoxymethyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester

: 102613-65-0
tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

: 55305-15-2
3,3'-bis-(2-methoxycarbonyl-ethyl)-4,4'-bis-methoxycarbonylmethyl-1H,1'H-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid dibenzyl ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 1.75h; Ambient temperature;

Reference yield:

: 7149-59-9
diethyl 3-oxoadipate

: 102613-65-0
tert-butyl 3,3'-bis<β-(methoxycarbonyl)ethyl>-4,4'--5'-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: 97.5 percent / 3 h / 150 - 160 °C

2: 1.) sodium nitrite, 2.) zinc dust, ammonium acetate / 1) acetic acid. 15 - 20 deg C, 1 d; 2) acetic acid, 90 - 100 deg C, 0. 5 h

3: 1.) thallium(III) nitrate trihydrate, nitric acid / 1) 30 h; 2) 1 d

4: 80.1 percent / sulphuryl chloride / CH₂Cl₂ / 2 h

5: 44.0 g / sulphuric acid / CHCl₃ / 40 h / Ambient temperature

6: H₂ / Pd/C / methanol / 35 °C

7: 91.7 percent / sodium hydrogen carbonate, iodine, potassium iodide / CHCl₃ / 0.42 h / Heating

8: 91.4 percent / H₂, sodium acetate, / Pd/C / methanol

9: 92 percent / toluene-p-sulphonic acid monohydrate / CH₂Cl₂ / 1.75 h / Ambient temperature

With ammonium acetate; sulfuryl dichloride; thallium(III) nitrate trihydrate; sulfuric acid; hydrogen; iodine; nitric acid; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; potassium iodide; zinc; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane; chloroform;