7149-59-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Oxohexanedioic Acid Diethyl Ester is used as an intermediate in the preparation of CMPF (C595000), a drug-binding inhibitor. CMPF is also a constituent of urine and can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors. This makes it a valuable compound in the development of drugs targeting specific binding interactions in the body.

InChI:InChI=1/C10H16O5/c1-3-14-9(12)6-5-8(11)7-10(13)15-4-2/h3-7H2,1-2H3

Upstream product

• 412305-43-2 2-oxo-butane-1,1,4-tricarboxylic acid-1,1-diethyl ester 
• 64-17-5 ethanol 
• 79930-26-0 ethyl 5-oxo-4-oxaspiro<2.3>hexane-1-carboxylate 
• 57691-01-7 ethyl (E)-5-oxotetrahydrofuran-2-ylideneacetate 
• 5457-44-3 dimethyl 3-oxoadipate 
• 1070-34-4 butanedioic acid, monoethyl ester 
• 6148-64-7 ethyl potassium malonate 
• 81803-80-7 4-(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)-4-oxo-butyric acid methyl ester 
• 2033-24-1 cycl-isopropylidene malonate 
• 996-82-7 sodium diethylmalonate 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 61975-86-8 ethyl 2,5-dihydro-2,3-dimethyl-5-oxoisoxazole-4-carboxylate 
• 133827-51-7 ethyl 3-(4-ethoxycarbonyl-5-hydroxyisoxazol-3-yl)-propionate 
• 133827-52-8 ethyl 3-methyl-5-oxo-2,5-dihydroisoxazole-4-carboxylate sodium salt 

Downstream Products

• 868-10-0 2-hydroxyimino-3-oxo-adipic acid diethyl ester 
• 31695-39-3 3-(2-ethoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester 
• 50622-87-2 ethyl 2-ethoxycarbonyl-4-benzyloxycarbonyl-5-methylpyrrole-3-propionate 
• 868-10-0 2-Oximino-3-oxo-adipinsaeure-diaethylester 
• 110830-24-5 (E)-3-(4-Chloro-phenylamino)-hex-2-enedioic acid diethyl ester 
• 80504-97-8 benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methyl<5-13C>pyrrole-2-carboxylate 
• 80505-10-8 benzyl 5-formyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl<5-13C>pyrrole-2-carboxylate 
• 40515-75-1 2-Methyl-pyrrol-carbonsaeureethylester-5-(β-propionsaeure-ethylester)-4 
• 5451-09-2 5-aminolevulinic acid hydrochloride 
• 71028-88-1 ethyl 3-(5,7-dihydroxy-2-oxo-2H-chromen-4-yl)propanoate 

Relevant academic research and scientific papers

PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS

The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers.

Preparation methods for 5-aminolevulinic acid hydrochloride and 5-aminolevulinic acid hydrochloride intermediate

The invention discloses preparation methods for a 5-aminolevulinic acid hydrochloride and a 5-aminolevulinic acid hydrochloride intermediate. The preparation method for the 5-aminolevulinic acid hydrochloride intermediate comprises: (1) carrying out a reaction on a compound 2 and isopropylidene malonate in an organic solvent under the actions of an organic alkali and a condensing agent to obtain acompound 3; and (2) carrying out a reaction on the compound 3 in a C1-C4 alcohol solvent to obtain a compound 4, wherein R1 and R' are respectively and independently C1-C4 alkyl. The present invention further provides a method for preparing a 5-aminolevulinic acid hydrochloride by using the 5-aminolevulinic acid hydrochloride intermediate. According to the present invention, the intermediate product is basically solid and is easily crystallized and purified; and the method has characteristics of high yield, low production cost and easy operation, and is suitable for industrial production. Thecompounds 1, 2, 3 and 4 are defined in the specification.

BENZOXAZEPINE COMPOUND

A compound represented by the formula [1]: wherein ring A and ring B each represent an optionally substituted benzene ring; ring C represents an optionally further substituted aromatic ring; R1 represents a lower alkyl group optionally substituted with an optionally substituted hydroxyl group; X1a represents a bond or optionally substituted lower alkylene; X1b represents a bond or optionally substituted lower alkylene; X2 represents a bond, -O- or -S-; X3 represents a bond or an optionally substituted divalent hydrocarbon group; Y represents an optionally esterified or amidated carboxyl group, or a salt thereof. The compound of the formula [I] is safer and has more potent lipid lowering activity such as squalene synthase inhibitory activity (cholesterol lowering activity) and triglyceride lowering activity, and thus it is a compound useful as an agent for preventing or treating hyperlipemia.

The reactions of diazo compounds with lactones. Part 1. Cyclopropanespiro-β-lactones from diketene: Synthesis and reactions

The cyclopropanespiro-β-lactones 3, 4 and 12 can be prepared by the metal catalysed, or photochemically promoted decomposition reactions of diazocompounds in the presence of diketene. The thermal reactions of these compounds give a variety of products depending on the nature of the spirolactone; these include a furan 9a, 1,4-dicarbonyl compounds 18a-c and 19b, a pyranone 20b, furanones 21a, 21f and 22a and the enol 16. The boron trifluoride promoted reaction of a mixture of 3b and 4b gives a 13-ketoacid. Mechanisms are proposed for the formation of these products. The rearrangment of the cyclopropanespiro-β-lactones to furan-2(5H)-ones and furan-2-(3H)-ones 6-8, 21a, 21f, 22a and 24 is shown to be a general reaction that involves metal catalysis. A mechanism based on formation of a metallocycle by a novel insertion of the metal into the C-O bond of the β-lactone ring is proposed for this rearrangement. This accounts for the observed features of the reaction.

Niobium pentachloride-mediated novel homologation reactions using α-trialkylstannylmethyl-β-keto esters

In the presence of niobium pentachloride (NbCl5), an α-trialkylstannylmethyl-β-keto ester is homologated to the corresponding γ-keto ester in good yield; the reaction mechanism is discussed.

Metal catalysed rearrangement of cyclopropanespiro-β-lactones to 2-furanones

The rearrangement of 5-oxo-4-oxaspiro[2.3]hexanes (cyclopropanespiro-β-lactones) to 2(5H)-furanones and 2(3H)-furanones is shown to be a general reaction which is promoted by metal catalysts. A mechanism is proposed, involving the novel insertion of a metal species into the O-C(β) bond of the β-lactone ring, which explains the basic features of the reaction, including its regioselectivity.

Preparation of γ-Substituted β-Oxoesters with a New Heterocyclic Synthon

Ethyl 2,5-dihydro-2,3-dimethyl-5-oxoisoxazole-4-carboxylate was alkylated and acylated via its potassium-salt generated by potassium t-butoxide under convenient conditions.Hydrolysis of the enamines obtained by the catalytic hydrogenation of the 3-alkylated/acetylated derivatives affords β-oxo and β,δ-dioxoesters, respectively.Hydrogenolysis of the 3-acyl derivatives allows the regiospecific synthesis of β-enamino-δ-oxoesters.

A NEW ENAMINE-SALT FOR THE SYNTHESIS OF γ-ALKYLATED ETHYL ACETOACETATE DERIVATIVES

A convenient method for the preparation of γ-alkylated ethyl acetoacetate from alkyl halides via a new isoxazole enamine-salts is reported.

AN IMPROVED SYNTHESIS OF 2-METHYL-4-(2'-CARBOXYETHYL)PYRROLE. POTENTIAL INHIBITORS OF PORPHOBILINOGEN DEAMINASE

Improved syntheses of 2-methyl-4-(2'-carboxyethyl)pyrrole (10) (49percent overall yield) and of several O- and S-containing β-(5-ring heterocyclic)-substituted propionic acid are described.Some of these compounds have been found to be inhibitors of porphobilinogen deaminase.