(+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H₆]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one

Base Information

• Chemical Name: (+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H₆]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one
• CAS No.: 137530-65-5
• Molecular Formula: C₂₀H₂₆O₃
• Molecular Weight: 320.377
• Mol file: 137530-65-5.mol

Synonyms:(+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H₆]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one

Chemical Property of (+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H₆]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H₆]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one

There total 1 articles about (+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H₆]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-hydroxy-3-pentyl-7,8-dihydrospiropyran-9,2'-<1,3>-dioxolan>-6(10H)-one (6469-57-4) + methyl-d3-magnesium iodide (41251-37-0) → (+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H6]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one (137530-65-5)

Guidance literature:

1-hydroxy-3-pentyl-7,8-dihydrospiropyran-9,2'-<1,3>-dioxolan>-6(10H)-one; methyl-d3-magnesium iodide; In tetrahydrofuran; diethyl ether; for 48h; Heating;

With hydrogenchloride; for 1.5h;

DOI:10.1002/1099-1344(200006)43:7<655::AID-JLCR350>3.0.CO;2-T

Reference yield:

(+/-)-6,6a,7,8-tetrahydro-1-hydroxy-6,6-[2H6]dimethyl-3-pentyl-9H-dibenzo[b,d]pyran-9-one (137530-65-5) → C35H46(2)H6N2O4S

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / liquid NH₃; Li / tetrahydrofuran / -78 °C

With ammonia; lithium; In tetrahydrofuran; 1: Reduction / 2: Condensation;

DOI:10.1002/1099-1344(200006)43:7<655::AID-JLCR350>3.0.CO;2-T

upstream raw materials:

1-hydroxy-3-pentyl-7,8-dihydrospiropyran-9,2'-<1,3>-dioxolan>-6(10H)-one

methyl-d3-magnesium iodide