1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

Base Information

Chemical Name:1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide
CAS No.:1453174-45-2
Molecular Formula:C₂₁H₂₃N₅O₄S
Molecular Weight:441.511
Hs Code.:

Synonyms:1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

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Chemical Property of 1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

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Technology Process of 1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

There total 7 articles about 1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 952182-02-4
1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid

: 1450723-83-7
1-(4-[[4-(aminomethyl)benzene]sulfonyl]piperidin-1-yl)ethan-1-one

: 1453174-45-2
1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 227617-15-4
4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

: 1453174-45-2
1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / 60 °C

2: triethylamine; hydrogen; 10 wt% Pd(OH)2 on carbon / tetrahydrofuran / 3 h / 20 °C

3: trifluoroacetic acid / 4 h / 80 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 227617-16-5
ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1453174-45-2
1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; hydrogen; 10 wt% Pd(OH)2 on carbon / tetrahydrofuran / 3 h / 20 °C

2: trifluoroacetic acid / 4 h / 80 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;