1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

Base Information

• Chemical Name: 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
• CAS No.: 952182-02-4
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.136
• Hs Code.: 2933990090
• Mol file: 952182-02-4.mol

Synonyms:1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID;4-b]pyridine-5-carboxylic acid

Chemical Property of 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 7.85E-10mmHg at 25°C
• Boiling Point: 475.1°C at 760 mmHg
• PKA: 10.24±0.40(Predicted)
• Flash Point: 241.1°C
• PSA: 78.87000
• Density: 1.617g/cm³
• LogP: 0.65610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

There total 8 articles about 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (1234616-67-1) → 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid (952182-02-4)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 15h; Inert atmosphere;

DOI:10.1021/acs.joc.7b01101

Reference yield: 80.0%

ethyl 1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b] pyridine-5-carboxylate (1086423-59-7) → 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid (952182-02-4)

Guidance literature:

With trifluoroacetic acid; at 80 ℃; for 4h;

Reference yield: 69.0%

1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester (1196156-42-9) → 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid (952182-02-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

upstream raw materials:

4-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

ethyl 1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b] pyridine-5-carboxylate

C₉H₉N₃O₂

Downstream raw materials:

1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-pyrrolidin-1-ylpiperidine-1-sulfonyl)benzylamide

4-{[(1H-pyrazolo[3_,4-b]pyridine-5-carbonyl)amino]methyl}benzenesulfonyl chloride

1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid benzylamide

1H-pyrazolo[3,4-b]pyridine-5-carboxyIic acid 4-(1-acetylpiperidine-4-sulfonyl)benzylamide

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