3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide

Base Information

• Chemical Name: 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide
• CAS No.: 181510-07-6
• Molecular Formula: C₁₈H₁₈N₂O₅S
• Molecular Weight: 374.417
• Mol file: 181510-07-6.mol

Synonyms:3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide

Chemical Property of 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide

There total 3 articles about 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propane-1-sulfonyl chloride (62605-69-0) + O-benzylhydoxylamine hydrochloride (2687-43-6) → 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide (181510-07-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/0960-894X(96)00307-1

Reference yield:

potassium 3‐(1,3‐dioxo‐2,3‐dihydro‐1H‐isoindol‐2‐yl)propane‐1‐sulfonate → 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide (181510-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / PCl₅ / benzene / Heating

2: 83 percent / Huenig's base / CH₂Cl₂

With phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene;

DOI:10.1016/0960-894X(96)00307-1

Reference yield:

potassium phtalimide (1074-82-4) → 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-amide (181510-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / ethanol / 2 h / Heating

2: 92 percent / PCl₅ / benzene / Heating

3: 83 percent / Huenig's base / CH₂Cl₂

With phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0960-894X(96)00307-1

upstream raw materials:

3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propane-1-sulfonyl chloride

O-benzylhydoxylamine hydrochloride

potassium phtalimide

Downstream raw materials:

{Benzyloxy-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonyl]-amino}-acetic acid

{Benzyloxy-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonyl]-amino}-acetic acid tert-butyl ester

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyl-benzyloxy-amide

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propane-1-sulfonic acid benzyloxy-methyl-amide