1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

Base Information

Chemical Name:1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole
CAS No.:1022930-30-8
Molecular Formula:C₁₈H₁₈F₃N₃O₂
Molecular Weight:365.355
Hs Code.:

Synonyms:1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

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Chemical Property of 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

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Technology Process of 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

There total 3 articles about 1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 168317-99-5
(4-iodophenyl)(pyrrolidin-1-yl)methanone

: 1022931-45-8
3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

: 1022930-30-8
1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

Guidance literature:: With caesium carbonate; copper(I) oxide; dimethylaminoacetic acid; In dimethyl sulfoxide; at 130 ℃; for 16h;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1022930-30-8
1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere

1.2: -70 - 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 9 h / 60 - 70 °C / Inert atmosphere

3.1: copper(I) oxide; dimethylaminoacetic acid; caesium carbonate / dimethyl sulfoxide / 16 h / 130 °C

With copper(I) oxide; dimethylaminoacetic acid; caesium carbonate; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm100679e

Reference yield:

: 158351-87-2
3-(trifluoroacetyl)tetrahydro-4H-pyran-4-one

: 1022930-30-8
1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 9 h / 60 - 70 °C / Inert atmosphere

2: copper(I) oxide; dimethylaminoacetic acid; caesium carbonate / dimethyl sulfoxide / 16 h / 130 °C

With copper(I) oxide; dimethylaminoacetic acid; caesium carbonate; hydrazine hydrate; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm100679e