1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE

Base Information

• Chemical Name: 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE
• CAS No.: 1022931-45-8
• Molecular Formula: C7H7F3N2O
• Molecular Weight: 192.141
• Hs Code.: 2934999090

Synonyms:1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE;3-(Trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

Chemical Property of 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE

Chemical Property:

• Boiling Point: 279.2 °C at 760 mmHg
• Flash Point: 122.6 °C
• PSA: 37.91000
• Density: 1.451 g/cm³
• LogP: 1.50120

Purity/Quality:

97% ^*data from raw suppliers

3-(Trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE

There total 3 articles about 1,4,6,7-TETRAHYDRO-3-(TRIFLUOROMETHYL)PYRANO-[4,3-C]-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(trifluoroacetyl)tetrahydro-4H-pyran-4-one (158351-87-2) → 3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole (1022931-45-8)

Guidance literature:

With hydrazine; In ethanol; at 60 - 70 ℃; for 9h;

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole (1022931-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere

1.2: -70 - 20 °C / Inert atmosphere

2.1: hydrazine hydrate / ethanol / 9 h / 60 - 70 °C / Inert atmosphere

With hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

DOI:10.1021/jm100679e

Reference yield:

→ 3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole (1022931-45-8)

Guidance literature:

upstream raw materials:

3-(trifluoroacetyl)tetrahydro-4H-pyran-4-one

Tetrahydro-4H-pyran-4-one

Downstream raw materials:

5-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

2-fluoro-4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]benzoic acid

4-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]benzoic acid

1-[4-(1-pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

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