(5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one

Base Information

• Chemical Name: (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one
• CAS No.: 1430324-81-4
• Molecular Formula: C₂₅H₃₀N₄O₇
• Molecular Weight: 498.536
• Mol file: 1430324-81-4.mol

Synonyms:(5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one

Chemical Property of (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one

There total 10 articles about (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5Z)-2-[4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-5-one (1430324-79-0) → (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one (1430324-81-4)

Guidance literature:

(5Z)-2-[4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-5-one; In tetrahydrofuran; for 24h; Reflux;

With water; In tetrahydrofuran; for 24h;

DOI:10.1016/j.ejmech.2013.01.035

Reference yield:

4-N-tert-butoxycarbonylaminophenol (54840-15-2) → (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one (1430324-81-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 48 h / 80 °C

2.1: triethylamine / dichloromethane / 24.33 h / 0 - 25 °C

3.1: sodium azide / water; ethanol / 1 h / 160 °C / Sealed tube; Microwave irradiation

4.1: hexane / 30?min / 160?°C / Sealed tube; Microwave irradiation

5.1: triphenylphosphine bounded on polymer / tetrahydrofuran / 24 h / Reflux

5.2: 24 h / 81?°C

With sodium azide; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.01.035

Reference yield:

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester (77544-60-6) → (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one (1430324-81-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 48 h / 80 °C

2.1: triethylamine / dichloromethane / 24.33 h / 0 - 25 °C

3.1: sodium azide / water; ethanol / 1 h / 160 °C / Sealed tube; Microwave irradiation

4.1: hexane / 30?min / 160?°C / Sealed tube; Microwave irradiation

5.1: triphenylphosphine bounded on polymer / tetrahydrofuran / 24 h / Reflux

5.2: 24 h / 81?°C

With sodium azide; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.01.035

upstream raw materials:

4-N-tert-butoxycarbonylaminophenol

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

tert-butyl N-[4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]phenyl]carbamate

2-[2-[2-[2-[4-(tert-butoxycarbonylamino)phenoxy]ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate