4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

Base Information

Chemical Name:4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside
CAS No.:1154463-83-8
Molecular Formula:C₂₉H₃₈Cl₃F₃N₂O₈Si
Molecular Weight:734.069
Hs Code.:

Synonyms:4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

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Chemical Property of 4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

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Technology Process of 4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

There total 4 articles about 4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4,6-O-di(tert-butyl)silylidene-2-deoxy-2-trichloroacetamido-D-glucopyranosyl N-phenyl-2,2,2-trifluoroacetimidate

: 123-76-2
levulinic acid

: 1154463-83-8
4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1021/ol301666n

Reference yield:

: 90-76-6,90-77-7,530-23-4,579-32-8,579-33-9,643-68-5,2596-19-2,6490-68-2,6490-70-6,6490-72-8,6490-73-9,6490-74-0,14196-84-0,14196-86-2,14257-69-3,58381-21-8
2-deoxy-2-amino glucose

: 1154463-83-8
4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 144 h / 20 °C

2: N,N-dimethyl-formamide / 1 h / -40 °C

3: caesium carbonate / acetone / 3.5 h / 0 - 20 °C

4: dmap; diisopropyl-carbodiimide / dichloromethane / 2.5 h / 0 °C

With dmap; caesium carbonate; triethylamine; diisopropyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol301666n

Reference yield:

: 4,6-O-di(tert-butyl)silylidene-2-deoxy-2-trichloroacetamido-D-glucopyranose

: 1154463-83-8
4,6-O-di-tert-butylsilylidene-3-O-levulinoyl-1-O-(N-phenyltrifluoroacetimidoyl)-2-N-trichloroacetamido-α/β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetone / 3.5 h / 0 - 20 °C

2: dmap; diisopropyl-carbodiimide / dichloromethane / 2.5 h / 0 °C

With dmap; caesium carbonate; diisopropyl-carbodiimide; In dichloromethane; acetone;
DOI:10.1021/ol301666n