1-benzyl-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:1-benzyl-1H-pyrazole-5-carboxylic acid
CAS No.:87581-74-6
Molecular Formula:C₁₁H₁₀N₂O₂
Molecular Weight:202.213
Hs Code.:
European Community (EC) Number:894-014-1

Synonyms:1-benzyl-1H-pyrazole-5-carboxylic acid;87581-74-6;2-benzylpyrazole-3-carboxylic acid;1-benzylpyrazole-5-carboxylic acid;SCHEMBL17869333;SFIGVCZYZFTEMK-UHFFFAOYSA-N;AKOS009859860;1-benzyl-1H-pyrazole-5-carboxylicacid;KS-10957;CS-0238954;EN300-203258;Z1230012814

Suppliers and Price of 1-benzyl-1H-pyrazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 1-benzyl-1H-pyrazole-5-carboxylic acid

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:202.074227566
Heavy Atom Count:15
Complexity:227

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN2C(=CC=N2)C(=O)O

Technology Process of 1-benzyl-1H-pyrazole-5-carboxylic acid

There total 6 articles about 1-benzyl-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 10199-67-4
1-benzylpyrazole

: 124-38-9,18923-20-1
carbon dioxide

: 87581-74-6
1-benzyl-1H-pyrazole-5-carboxylic acid

: 87581-64-4
α-(1-pyrazolyl)phenylacetic acid

Guidance literature:: 1-benzylpyrazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: ethyl 1-benzyl-1H-pyrazole-5-carboxylate

: 87581-74-6
1-benzyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 25 ℃; for 2h;

Reference yield:

: 100-39-0
benzyl bromide

: 87581-74-6
1-benzyl-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 25 °C

2: sodium hydroxide / methanol / 2 h / 25 °C

With potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;