Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

Base Information

Chemical Name:Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester
CAS No.:86462-53-5
Molecular Formula:C₂₉H₃₈N₂O₅
Molecular Weight:494.631
Hs Code.:

Synonyms:Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

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Chemical Property of Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

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Technology Process of Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

There total 8 articles about Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60989-82-4
(2S,3S)-(–)-2,3-di(hydroxymethyl)-1,4-dioxaspiro[4.5]decane

: 86462-53-5
Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / NaH

2: 1.) TsCl; 2.) NaBH₄ / 1.) pyridine

3: H₂ / Pd/C

4: 87 percent / (COCl)2, Et₃N / dimethylsulfoxide

5: diethyl ether / 0.5 h / 0 °C

6: zinc bromide / tetrahydrofuran / 2.5 h / 0 °C

7: NaHCO₃ / diethyl ether; H₂O / 0.5 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; p-toluenesulfonyl chloride; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1246/cl.1983.671

Reference yield:

: 933-40-4
cycloxexanone dimethyl ketal

: 86462-53-5
Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 2.) LiAlH₄

2: 88 percent / NaH

3: 1.) TsCl; 2.) NaBH₄ / 1.) pyridine

4: H₂ / Pd/C

5: 87 percent / (COCl)2, Et₃N / dimethylsulfoxide

6: diethyl ether / 0.5 h / 0 °C

7: zinc bromide / tetrahydrofuran / 2.5 h / 0 °C

8: NaHCO₃ / diethyl ether; H₂O / 0.5 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; p-toluenesulfonyl chloride; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1246/cl.1983.671

Reference yield:

: 107290-98-2
(+)-(2S,3S)-3-benzyloxymethyl-2-hydroxymethyl-1,4-dioxaspiro<4,5>decane

: 86462-53-5
Benzyl-[(S)-2-dimethylcarbamoyl-1-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) TsCl; 2.) NaBH₄ / 1.) pyridine

2: H₂ / Pd/C

3: 87 percent / (COCl)2, Et₃N / dimethylsulfoxide

4: diethyl ether / 0.5 h / 0 °C

5: zinc bromide / tetrahydrofuran / 2.5 h / 0 °C

6: NaHCO₃ / diethyl ether; H₂O / 0.5 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; triethylamine; p-toluenesulfonyl chloride; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1246/cl.1983.671