(S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide

Base Information

Chemical Name:(S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide
CAS No.:86462-52-4
Molecular Formula:C₂₁H₃₂N₂O₃
Molecular Weight:360.497
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide

Chemical Property:

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Technology Process of (S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide

There total 7 articles about (S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60989-82-4
(2S,3S)-(–)-2,3-di(hydroxymethyl)-1,4-dioxaspiro[4.5]decane

: 86462-52-4
(S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / NaH

2: 1.) TsCl; 2.) NaBH₄ / 1.) pyridine

3: H₂ / Pd/C

4: 87 percent / (COCl)2, Et₃N / dimethylsulfoxide

5: diethyl ether / 0.5 h / 0 °C

6: zinc bromide / tetrahydrofuran / 2.5 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium hydride; triethylamine; p-toluenesulfonyl chloride; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1246/cl.1983.671

Reference yield:

: 933-40-4
cycloxexanone dimethyl ketal

: 86462-52-4
(S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: 2.) LiAlH₄

2: 88 percent / NaH

3: 1.) TsCl; 2.) NaBH₄ / 1.) pyridine

4: H₂ / Pd/C

5: 87 percent / (COCl)2, Et₃N / dimethylsulfoxide

6: diethyl ether / 0.5 h / 0 °C

7: zinc bromide / tetrahydrofuran / 2.5 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; sodium hydride; triethylamine; p-toluenesulfonyl chloride; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1246/cl.1983.671

Reference yield:

: 107290-98-2
(+)-(2S,3S)-3-benzyloxymethyl-2-hydroxymethyl-1,4-dioxaspiro<4,5>decane

: 86462-52-4
(S)-3-Benzylamino-N,N-dimethyl-3-((2S,3S)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) TsCl; 2.) NaBH₄ / 1.) pyridine

2: H₂ / Pd/C

3: 87 percent / (COCl)2, Et₃N / dimethylsulfoxide

4: diethyl ether / 0.5 h / 0 °C

5: zinc bromide / tetrahydrofuran / 2.5 h / 0 °C

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; triethylamine; p-toluenesulfonyl chloride; zinc dibromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1246/cl.1983.671