4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Base Information

Chemical Name:4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one
CAS No.:1338797-31-1
Molecular Formula:C₂₂H₂₄BrNO₃
Molecular Weight:430.341
Hs Code.:

Synonyms:4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

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Chemical Property of 4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

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Technology Process of 4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

There total 11 articles about 4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1338796-89-6
1-bromo-4-phenyl-5,6,8,9-tetrahydrobenzocyclohepten-7-one

: 1338797-32-2
1-bromo-4-phenyl-7-tert-butyloxycarbonylamino-5,7,8,9-tetrahydro-benzocyclohepten-6-one

: 1338797-31-1
4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Guidance literature:: 1-bromo-4-phenyl-5,6,8,9-tetrahydrobenzocyclohepten-7-one; With trimethylsilyl trifluoromethanesulfonate; triethylamine; In toluene; at 80 ℃; for 4h; Inert atmosphere;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

di-tert-butyl dicarbonate; Further stages;
DOI:10.1016/j.bmc.2011.06.089

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1338797-52-6
C₁₇H₁₈BrNO

: 1338797-31-1
4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Guidance literature:: di-tert-butyl dicarbonate; C₁₇H₁₈BrNO; With sodium carbonate; In methanol; at 25 ℃;

With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 2h;
DOI:10.3390/molecules23102607

Reference yield:

: C₂₃H₂₉BrO₂Si

: 1338797-31-1
4-bromo-7-(tert-butoxycarbonylamino)-1-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / pyridine / 5 h / 25 °C

1.2: 2 h / 25 °C

2.1: sodium tetrahydroborate; cobalt(II) chloride hexahydrate / methanol / 2 h / -30 - 25 °C

3.1: sodium carbonate / methanol / 25 °C

3.2: 2 h / 25 °C

With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; hydroxylamine hydrochloride; sodium carbonate; In pyridine; methanol;
DOI:10.3390/molecules23102607