Chloroacetylferrocene

Base Information

• Chemical Name: Chloroacetylferrocene
• CAS No.: 51862-24-9
• Molecular Formula: C12H13ClFeO
• Molecular Weight: 262.519
• Mol file: 51862-24-9.mol

Synonyms:chloroacetylferrocene

Chemical Property of Chloroacetylferrocene

Chemical Property:

• PSA: 17.07000
• LogP: 2.81340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Chloroacetylferrocene

There total 1 articles about Chloroacetylferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

ferrocene (102-54-5,55404-68-7) + chloroacetyl chloride (79-04-9) → acetylferrocene (1271-55-2) + 2-chloro-1-ferrocenylethanone (51862-24-9)

Guidance literature:

With AlCl₃; In dichloromethane; dropwise addn. of equimolar amt. of org. chloride and portionwise addn. f equimolar amt. of AlCl3 to Fe-complex soln. simultaneously at 0°C over 20 min, stirring for 40 min; pouring onto ice-cold water, extn. of aq. layer into CH2Cl2, washing of combined org. fractions (H2O), drying, evapn., chromy. (Al2O3, petroleumether);

DOI:10.1016/S0022-328X(96)06642-9

Reference yield: 88.0%

4-Methoxyphenylacetic acid (104-01-8) + 2-chloro-1-ferrocenylethanone (51862-24-9) → 2-oxo-2-ferrocenylethyl 2-(4-methoxyphenyl)acetate (1353572-83-4)

Guidance literature:

With triethylamine; sodium iodide; In acetone; for 4h; Reflux; Inert atmosphere;

DOI:10.1039/c2ob26226f

Reference yield: 87.0%

2-chloro-1-ferrocenylethanone (51862-24-9) + 3-(4-methoxyphenyl)-1H-1,2,4-triazole-5-thiol (33901-36-9) → 1-ferrocenyl-2-(3-(4-methoxyphenyl)-1H-1,2,4-triazol-5-ylthio)ethanone (1236188-36-5)

Guidance literature:

With NaH; KI; In toluene; refluxing a mixt. of thiol, NaH in mineral oil, KI, iron complex and toluene for 3-4 h, cooling; pouring into cold water, extn. with ethyl acetate, drying over MgSO4, filtration, evapn. in vac., column chromy. (silica gel);

DOI:10.1016/j.saa.2010.04.019

upstream raw materials:

ferrocene

chloroacetyl chloride

Downstream raw materials:

vinyl ferrocene

9-[4-(1-ferrocenoylmethoxy)phenyl]-10-(4-methoxyphenyl)anthracene