N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:133167-60-9
Molecular Formula:C₁₇H₁₄ClN₅O₄
Molecular Weight:387.782
Hs Code.:

Synonyms:N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

There total 5 articles about N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 133167-58-5,133167-59-6
N-(9-{(3aR,4R,6aS)-6-[1-Chloro-meth-(Z)-ylidene]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

: 133167-60-9
N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With trifluoroacetic acid; In water;
DOI:10.1021/jm00106a028

Reference yield:

: 133167-56-3,133191-03-4
N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-benzenesulfinylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

: 133167-60-9
N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / SO₂Cl₂, pyridine / CH₂Cl₂ / 0.33 h

2: 64 percent / EtN(iPr)2 / bis-(2-methoxy-ethyl) ether / Heating

3: 60 percent / CF₃COOH / H₂O

With pyridine; sulfuryl dichloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; diethylene glycol dimethyl ether; water;
DOI:10.1021/jm00106a028

Reference yield:

: 133167-55-2
N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

: 133167-60-9
N-(9-{(2R,3R,4S)-5-[1-Chloro-meth-(Z)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / 3-chloroperbenzoic acid / CH₂Cl₂

2: 60 percent / SO₂Cl₂, pyridine / CH₂Cl₂ / 0.33 h

3: 64 percent / EtN(iPr)2 / bis-(2-methoxy-ethyl) ether / Heating

4: 60 percent / CF₃COOH / H₂O

With pyridine; sulfuryl dichloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; diethylene glycol dimethyl ether; water;
DOI:10.1021/jm00106a028