N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide
CAS No.:133167-55-2
Molecular Formula:C₃₄H₃₁N₅O₆S
Molecular Weight:637.716
Hs Code.:

Synonyms:N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

There total 1 articles about N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 119244-39-2
9-[(3aR,4R,6S,6aS)-6-(4-Methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-ylamine

: 98-88-4
benzoyl chloride

: 133167-55-2
N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With pyridine;
DOI:10.1021/jm00106a028

Reference yield: 55.0%

: 133167-55-2
N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

: 133167-56-3,133191-03-4
N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-benzenesulfinylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm00106a028

Reference yield:

: 133167-55-2
N-Benzoyl-N-{9-[(3aR,4R,6S,6aS)-6-(4-methoxy-phenylsulfanylmethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide

: 133167-65-4
N-(9-{(2R,3R,4S)-5-[1-Chloro-1-fluoro-meth-(E)-ylidene]-3,4-dihydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / 3-chloroperbenzoic acid / CH₂Cl₂

2: 46 percent / (diethylamido)sulfur triluoride (DAST) / CHCl₃

3: 60 percent / 3-chloroperbenzoic acid / CH₂Cl₂

4: 31 percent / SO₂Cl₂, pyridine / CH₂Cl₂

5: 45 percent / EtN(iPr)2 / bis-(2-methoxy-ethyl) ether / 18 h / Heating

6: CF₃COOH / H₂O / 22 h / Ambient temperature

With pyridine; sulfuryl dichloride; (diethylamido)sulfur triluoride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; chloroform; diethylene glycol dimethyl ether; water;
DOI:10.1021/jm00106a028