N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

Base Information

Chemical Name:N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol
CAS No.:82924-17-2
Molecular Formula:C₂₆H₃₅NO₃
Molecular Weight:409.569
Hs Code.:

Synonyms:N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

Chemical Property:

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Technology Process of N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

There total 3 articles about N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72297-80-4
1-[((S)-3-iodo-2-methylpropoxy)methyl]benzene

: 82924-16-1
1-(4-phenylbutyryl)-L-prolinol

: 82924-17-2
N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, 0 deg C, 30 min, 2.) THF, a) 0 deg C, 5 h, b) -15 deg C, 15 h;
DOI:10.1021/jm00363a012

Reference yield:

: 18496-54-3
phenylbutyric acid chloride

: 82924-17-2
N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1 N aq. NaOH / CH₂Cl₂ / a) 0 deg C, 4 h, b) RT, 1 h

2: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 30 min, 2.) THF, a) 0 deg C, 5 h, b) -15 deg C, 15 h

With sodium hydroxide; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00363a012

Reference yield:

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 82924-17-2
N-<(2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoyl>-L-prolinol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 1 N aq. NaOH / CH₂Cl₂ / a) 0 deg C, 4 h, b) RT, 1 h

2: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 30 min, 2.) THF, a) 0 deg C, 5 h, b) -15 deg C, 15 h

With sodium hydroxide; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00363a012