Technology Process of C19H20N4O
There total 5 articles about C19H20N4O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
glycolamide;
With
triethyloxonium fluoroborate;
In
tetrahydrofuran;
at 20 ℃;
for 3.5h;
trans-[4-(3-amino-quinolin-4-ylamino)-cyclohexyl]-acetonitrile;
In
ethanol;
at 75 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 20 °C / Reflux
3.1: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethyl acetate / 4 h / Inert atmosphere
4.1: triethyloxonium fluoroborate / tetrahydrofuran / 3.5 h / 20 °C
4.2: 1 h / 75 °C
With
palladium on activated charcoal; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / dichloromethane / 5 h / 0 - 20 °C
2.1: dimethyl sulfoxide / 4 h / 90 °C
3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 20 °C / Reflux
5.1: hydrogen; palladium on activated charcoal / tetrahydrofuran; ethyl acetate / 4 h / Inert atmosphere
6.1: triethyloxonium fluoroborate / tetrahydrofuran / 3.5 h / 20 °C
6.2: 1 h / 75 °C
With
pyridine; palladium on activated charcoal; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol;
