598-42-5

Basic information

• Product Name: 2-HYDROXYACETAMIDE
• Synonyms: 2-HYDROXYACETAMIDE;A-HYDROXYACETAMIDE;ALPHA-HYDROXYACETAMIDE;GLYCOLAMIDE;TIMTEC-BB SBB010080;Glycolamide,2-Hydroxyacetamide;GlycolaMide 98%;2-Hydroxyacetimidic acid
• CAS NO: 598-42-5
• Molecular Formula: C₂H₅NO₂
• Molecular Weight: 75.07
• Mol File: 598-42-5.mol

Chemical Properties

• Melting Point: 118-120 °C(lit.)
• Boiling Point: 133.7°C (rough estimate)
• Flash Point: 158.498 °C
• Appearance: /
• Density: 1.415 g/cm3 (-5℃)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.4264 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.28±0.10(Predicted)
• Water Solubility: 413.5g/L(25 oC)
• CAS DataBase Reference: 2-HYDROXYACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYACETAMIDE(598-42-5)
• EPA Substance Registry System: 2-HYDROXYACETAMIDE(598-42-5)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 598-42-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDROXYACETAMIDE is used as an intermediate in the preparation of phosphoglycolamide, which has potential applications in the development of pharmaceutical compounds.
Used in Chemical Research:
2-HYDROXYACETAMIDE serves as a subject of study for its conformational analysis, thermodynamic properties, and other physical and chemical characteristics, contributing to the understanding of its behavior in different environments and potential uses in chemical research and development.

InChI:InChI=1/C2H5NO2/c3-2(5)1-4/h4H,1H2,(H2,3,5)

Upstream product

• 623-86-9 acetoxy-acetic acid ethyl ester 
• 7664-41-7 ammonia 
• 7440-23-5 sodium 
• 74-90-8 hydrogen cyanide 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 35249-89-9 glycolic acid ammonium salt 
• 19115-34-5 2-ethoxy-2-oxoethyl benzoate 
• 64649-43-0 (aminocarbonyl)methyl benzoate 
• 71-36-3 butan-1-ol 
• 107-16-4 glycolonitrile 

Downstream Products

• 65424-62-6 phosphoglycolamide 
• 65298-21-7 2-(2,6-dichloro-phenyl)-oxazolidin-4-one 
• 199939-07-6 2-(2-bromophenyl)-1,3-oxazolidin-4-one 
• 79-14-1 glycolic Acid 
• 7664-41-7 ammonia 
• 821795-45-3 2-{4-[(1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonylpyrrolidin-2-yl)methyl]-3-(2-methylallyl)pyridin-2-yloxy}acetamide 
• 5704-04-1 N-[tris(hydroxymethyl)methyl]glycine 
• 141-43-5 ethanolamine 
• 39522-26-4 6-methyl-4H-benzo[1,4]oxazin-3-one 
• 89976-75-0 6-amino-2H-1,4-benzoxazin-3(4H)-one 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 5023-12-1 6-methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1315499-38-7 cyclohexyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-ylmethanol 
• 1418002-21-7 C₁₉H₂₀N₄O 

Relevant articles and documents

Methanol or formaldehyde ammoxidizing method of synthesizing amide

The invention relates to a methanol or formaldehyde ammoxidizing the method of synthesizing amide. Using methanol or formaldehyde, ammonia and air as the raw materials, in 1-3 gas reactor is continuously carried out in a catalytic reaction, synthesis (C-C) is provided with a carbon-carbon single bond or carbon-carbon-carbon single bond amide (C-C-C) organic compound (called C 2 or C 3 amide, mainly hydroxy acetamide, amino acetamide, diglycolamidic amide, malonamide and nitrilo- three b amide).

Synthesis of α-amino and α-hydroxy acids under volcanic conditions: implications for the origin of life

Facile synthesis of α-hydroxy and α-amino acids is observed at temperatures from 145 to 280 °C with catalytic Ni2+, with cyano ligands as source for C and N, and with CO as a reductant and as a source for C. Implications for the problem of the origin of life are discussed.

METHOD FOR THE PRODUCTION OF GLYCOLIC ACID FROM AMMONIUM GLYCOLATE BY DIRECT DEAMMONIATION

The present invention relates to a method for obtaining glycolic acid by direct deammoniation of ammonium glycolate. More specifically, water is removed from an aqueous solution of ammonium glycolate to produce the substantially anhydrous salt. Thermal salt cracking is then used to remove ammonia from the salt, producing a deammoniated product that is comprised of glycolic acid, oligomers of glycolic acid, glycolamide, and unreacted ammonium glycolate. The deammoniated product can be further hydrolyzed to convert oligomers of glycolic acid to additional quantities of glycolic acid.

HYDRATION OF CYANOHYDRINS IN WEEKLY ALKALINE SOLUTIONS OF BORIC ACID SALTS

α-Hydroxyamides and α-hydroxyacids were prepared in satisfactory yield by heating aldehyde-derived cyanohydrins in aqueous solution in the presence of borax or alkaline borates.