4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Base Information

Chemical Name:4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine
CAS No.:1332876-83-1
Molecular Formula:C₁₆H₁₅F₃N₄O₃
Molecular Weight:368.315
Hs Code.:

Synonyms:4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Suppliers and Price of 4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Chemical Property:

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Technology Process of 4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

There total 4 articles about 4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1332874-96-0
4-chloro-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

: 1332876-83-1
4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1332876-83-1
4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere

2.1: sulfuric acid / 1 h / 0 °C

2.2: 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With sulfuric acid; potassium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 116632-24-7
2-amino-4,6-dichloropyridine

: 1332876-83-1
4-morpholin-4-yl-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere

2.1: sulfuric acid / 1 h / 0 °C

2.2: 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With sulfuric acid; potassium carbonate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;