(S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Base Information

• Chemical Name: (S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal
• CAS No.: 1255928-86-9
• Molecular Formula: C₁₄H₁₄ClNO₃
• Molecular Weight: 279.723
• Mol file: 1255928-86-9.mol

Synonyms:(S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Chemical Property of (S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal

There total 2 articles about (S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(4-chlorophenyl)maleimide (1631-29-4) + isobutyraldehyde (78-84-2) → (S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1255928-86-9)

Guidance literature:

With C₃₀H₄₅N₃O₄; benzoic acid; In toluene; at 20 ℃; enantioselective reaction;

DOI:10.1016/j.tetlet.2017.10.026

Reference yield:

N-(4-chlorophenyl)maleimide (1631-29-4) + isobutyraldehyde (78-84-2) → (R)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1258548-40-1) + (S)-2-(1-(4-chlorophenyl)-2,5-dioxopyrrolidin-3-yl)-2-methylpropanal (1255928-86-9)

Guidance literature:

With (S)-1-(1-amino-3-phenylpropan-2-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; In dichloromethane; at 20 ℃; for 46h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2011.09.006

upstream raw materials:

N-(4-chlorophenyl)maleimide

isobutyraldehyde