(3S)-3-hydroxy-2,2-dimethyl-3-phenylpropanoic acid

Base Information

Chemical Name:(3S)-3-hydroxy-2,2-dimethyl-3-phenylpropanoic acid
CAS No.:61914-40-7
Molecular Formula:C₁₁H₁₄O₃
Molecular Weight:194.23
Hs Code.:

Synonyms:(S)-2,2-dimethyl-3-hydroxy-3-phenylpropanoic acid

Suppliers and Price of (3S)-3-hydroxy-2,2-dimethyl-3-phenylpropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-3-hydroxy-2,2-dimethyl-3-phenylpropanoic acid

Chemical Property:

Vapor Pressure:4.42E-05mmHg at 25°C

Purity/Quality:

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Technology Process of (3S)-3-hydroxy-2,2-dimethyl-3-phenylpropanoic acid

There total 7 articles about (3S)-3-hydroxy-2,2-dimethyl-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 79-31-2
isobutyric Acid

: 127852-67-9
(-)-(R)-3-hydroxy-2,2-dimethyl-3-phenylpropionic acid

: 61914-40-7
(S)-2,2-dimethyl-3-hydroxy-3-phenylpropanoic acid

Guidance literature:: isobutyric Acid; With chlorotriethoxysilane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

benzaldehyde; With tetraacetyl diborate; ((4-(dimethylamino)-2,3,5,6-tetrafluorophenyl)sulfonyl)-L-valine; In tetrahydrofuran; at 20 ℃; for 12h; stereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.202109788

Reference yield:

: 486447-61-4
3-acetoxy-2,2-dimethyl-3-phenyl-propionic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

: 61914-40-7
(S)-2,2-dimethyl-3-hydroxy-3-phenylpropanoic acid

Guidance literature:: With ammonium cerium(IV) nitrate; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1248/cpb.50.1131

Reference yield:

: 100-52-7
benzaldehyde

: 61914-40-7
(S)-2,2-dimethyl-3-hydroxy-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA; (R,R)-1,2-diphenylethandiol (2-methoxy)ethyl diether / hexane; toluene / 1 h / -78 °C

1.2: hexane; toluene / 0.08 h / -78 °C

2.1: Et₃N; DMAP / CH₂Cl₂ / 0.33 h / 20 °C

3.1: aq. cerium(IV) diammonium nitrate / acetonitrile / 2 h / 20 °C

With dmap; ammonium cerium(IV) nitrate; (R,R)-1,2-diphenylethandiol (2-methoxy)ethyl diether; triethylamine; lithium diisopropyl amide; In hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1248/cpb.50.1131