bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

Base Information

Chemical Name:bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane
CAS No.:1453106-70-1
Molecular Formula:C₂₅H₂₄N₈O₂
Molecular Weight:468.518
Hs Code.:

Synonyms:bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

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Chemical Property of bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

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Technology Process of bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

There total 5 articles about bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1453106-63-2
bis((4S,5S)-4-(azidomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

: 1066-26-8
sodium acetylide

: 1453106-70-1
bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; dimethyl sulfoxide; at 20 ℃; for 18h; Inert atmosphere; Schlenk technique;
DOI:10.1002/ejoc.201300279

Reference yield:

: 10344-69-1
diethyl malonoimidate dihydrochloride

: 1453106-70-1
bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 18 h / Inert atmosphere; Schlenk technique; Reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

3: sodium azide / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere; Schlenk technique

4: dimethyl sulfoxide; 5,5-dimethyl-1,3-cyclohexadiene / 18 h / 20 °C / Inert atmosphere; Schlenk technique

With sodium azide; carbon tetrabromide; triphenylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300279

Reference yield:

: 1453106-62-1
bis((4R,5S)-4-(bromomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

: 1453106-70-1
bis((4S,5S)-4-((1H-1,2,3-triazol-1-yl)methyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere; Schlenk technique

2: dimethyl sulfoxide; 5,5-dimethyl-1,3-cyclohexadiene / 18 h / 20 °C / Inert atmosphere; Schlenk technique

With sodium azide; In 5,5-dimethyl-1,3-cyclohexadiene; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300279