5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol

Base Information

• Chemical Name: 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol
• CAS No.: 1429183-44-7
• Molecular Formula: C₁₅H₁₅N₅O₄S
• Molecular Weight: 361.381
• Mol file: 1429183-44-7.mol

Synonyms:5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol

Chemical Property of 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol

There total 5 articles about 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.1%

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methylphenol (1357083-07-8) + 1-(2-bromoethyl)-2-methyl-5-nitroimidazole (6058-57-7) → 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol (1429183-44-7)

Guidance literature:

With sodium ethanolate; In ethanol; Reflux;

DOI:10.1016/j.bmc.2013.02.008

Reference yield:

ethyl 4-methylsalicylate (60770-00-5) → 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol (1429183-44-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / Reflux

2: potassium hydroxide / ethanol / Reflux

3: sodium ethanolate / ethanol / Reflux

With sodium ethanolate; hydrazine hydrate; potassium hydroxide; In ethanol;

DOI:10.1016/j.bmc.2013.02.008

Reference yield:

metronidazole (443-48-1) → 5-Methyl-2-(5-((2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)thio)-1,3,4-oxadiazol-2-yl)phenol (1429183-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine; phosphorus trichloride / ethyl acetate / 3 h / Reflux

1.2: pH 5 - 6

2.1: sodium ethanolate / ethanol / Reflux

With bromine; sodium ethanolate; phosphorus trichloride; In ethanol; ethyl acetate;

DOI:10.1016/j.bmc.2013.02.008

upstream raw materials:

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methylphenol

1-(2-bromoethyl)-2-methyl-5-nitroimidazole

2-hydroxy-4-methylbenzohydrazine

ethyl 4-methylsalicylate