Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate

Base Information

• Chemical Name: Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate
• CAS No.: 236744-59-5
• Molecular Formula: C₁₇H₂₈O₂
• Molecular Weight: 264.408
• Mol file: 236744-59-5.mol

Synonyms:Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate

Chemical Property of Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate

There total 7 articles about Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on (17283-81-7) → Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate (236744-59-5)

Guidance literature:

With sodium; In ethanol; for 2h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<522::AID-HLCA522>3.0.CO;2-5

Reference yield:

4-(1-Hydroxy-2,2,6-trimethylcyclohexyl)-3-butyn-2-ol (41641-09-2) → Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate (236744-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / H₂ / Raney nickel W₅ / ethanol / 24 h / 120 °C / 38000 Torr

2: 96 percent / H₂SO₄ aq / methanol / 2 h / Ambient temperature

3: 90 percent / Na₂Cr₂O₇*H₂O, H₂SO₄ conc. / benzene; H₂O; acetic acid / Ambient temperature

4: 1.) NaH / 1.) THF, room temp., 1 h, 2.) THF, room temp., 18 h

With sodium dichromate; sulfuric acid; hydrogen; sodium hydride; Raney nickel W₅; In methanol; ethanol; water; acetic acid; benzene;

DOI:10.1055/s-1982-29808

Reference yield:

4-(2,6,6-trimethyl-cyclohex-1-enyl)-butan-2-ol (446293-91-0,446293-94-3,3293-47-8) → Ethyl 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoate (236744-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Na₂Cr₂O₇*H₂O, H₂SO₄ conc. / benzene; H₂O; acetic acid / Ambient temperature

2: 1.) NaH / 1.) THF, room temp., 1 h, 2.) THF, room temp., 18 h

With sodium dichromate; sulfuric acid; sodium hydride; In water; acetic acid; benzene;

DOI:10.1055/s-1982-29808

upstream raw materials:

4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on

1-ethoxyacetylene

diethoxyphosphoryl-acetic acid ethyl ester

4-(2,6,6-trimethyl-cyclohex-1-enyl)-butan-2-ol

Downstream raw materials:

(E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-en-1'-yl)pent-2-en-1-ol

(E) 3-Methyl-5-(2,2,6-trimethylcyclohexen-1-yl)-2-pentenoic Acid

Bicyclofarnesic acid

Methyl (E)-3-methyl-5-(2,6,6-trimethylcyclohexen-1-yl)-2-pentenoate