2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one

Base Information

• Chemical Name: 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one
• CAS No.: 1309571-74-1
• Molecular Formula: C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.744
• Mol file: 1309571-74-1.mol

Synonyms:2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one

Chemical Property of 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one

There total 6 articles about 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-chloro-N-(2-(4,5-dihydrooxazol-2-yl)phenyl)benzamide → 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one (1309571-74-1)

Guidance literature:

With water; In acetone; at 100 ℃; for 6h; Green chemistry;

DOI:10.1039/d0ob00881h

Reference yield: 65.0%

2-(2-chlorophenyl)benzo[d]1,3-oxazin-4-one (4765-51-9) + ethanolamine (141-43-5) → 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one (1309571-74-1)

Guidance literature:

for 4h; Reflux;

DOI:10.1007/s00044-011-9621-5

Reference yield:

anthranilic acid nitrile (1885-29-6) → 2-(2-chlorophenyl)-3-(2-hydroxyethyl)quinazolin-4(3H)-one (1309571-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc(II) chloride / chlorobenzene / 36 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 10 h / 20 °C

3: water / acetone / 6 h / 100 °C / Green chemistry

With water; triethylamine; zinc(II) chloride; In dichloromethane; chlorobenzene; acetone;

DOI:10.1039/d0ob00881h

upstream raw materials:

2-(2-chlorophenyl)benzo[d]1,3-oxazin-4-one

ethanolamine

o-chlorobenzoyl chloride

anthranilic acid

Downstream raw materials:

2-amino-5-{2-[(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl}benzoic acid

2,3-bis(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxo(quinazolin-3-yl)]ethyl}quinazolin-4-one

3-(4-bromophenyl)-2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl}quinazolin-4-one

2-(2-chlorophenyl)-6-{2-[2-(2-chlorophenyl)-4-oxoquinazolin-3-yl]ethyl}benzo[d]1,3-oxazin-4-one