9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Base Information

Chemical Name:9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine
CAS No.:705254-57-5
Molecular Formula:C₅₅H₅₃N₅O₈
Molecular Weight:912.055
Hs Code.:

Synonyms:9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Suppliers and Price of 9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

There total 9 articles about 9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 705254-56-4
9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

: 705254-57-5
9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Guidance literature:: With pyridine; at 20 ℃; for 72h;
DOI:10.1039/b316304k

Reference yield: 26.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 705254-56-4
9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

: (E)-2-N-isobutyryl-9-[2-(dimethoxytrityloxymethyl)-3-hydroxyprop-1-enyl]guanine

: (Z)-2-N-isobutyryl-9-[2-(dimethoxytrityloxymethyl)-3-hydroxyprop-1-enyl]guanine

: 705254-57-5
9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Guidance literature:: With pyridine; at 20 ℃; for 48h;
DOI:10.1039/b517504f

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 705254-57-5
9-[3-dimethoxytrityloxy-2-(dimethoxytrityloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 8 steps

1: 67 percent / K₂CO₃ / dimethylformamide / 8 h / 110 °C

2: 85 percent / NaH; 3-hydroxypropionitrile / tetrahydrofuran / 4 h / 20 °C

3: 68 percent / pyridine / 672 h / 50 °C

4: pyridine / 0.5 h

5: 1.90 g / S₈ / 1 h

6: 58 percent / NaH; tert-amyl alcohol / tetrahydrofuran / 27 h / 20 °C

7: BCl₃ / CH₂Cl₂ / 3 h / -78 °C

8: 55 percent / pyridine / 72 h / 20 °C

With pyridine; sulfur; tert-Amyl alcohol; boron trichloride; sodium hydride; potassium carbonate; 3-Hydroxypropionitrile; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b316304k