2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

Base Information

Chemical Name:2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine
CAS No.:663193-17-7
Molecular Formula:C₂₃H₂₄ClN₅O₃
Molecular Weight:453.928
Hs Code.:

Synonyms:2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

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Chemical Property of 2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

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Technology Process of 2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

There total 1 articles about 2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 10310-21-1
2-Amino-6-chloropurin

: 27441-81-2
2,2-bis((benzyloxy)methyl)oxirane

: 663193-17-7
2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 6h;
DOI:10.1081/NCN-120022621

Reference yield: 85.0%

: 663193-17-7
2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

: 663193-21-3
2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]guanine

Guidance literature:: With sodium β-cyanoethoxide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1081/NCN-120022621

Reference yield:

: 663193-17-7
2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

: 705254-55-3
9-[3-benzyloxy-2-(benzyloxymethyl)prop-1-enyl]-N-2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / NaH; 3-hydroxypropionitrile / tetrahydrofuran / 4 h / 20 °C

2: 68 percent / pyridine / 672 h / 50 °C

3: pyridine / 0.5 h

4: 1.90 g / S₈ / 1 h

5: 58 percent / NaH; tert-amyl alcohol / tetrahydrofuran / 27 h / 20 °C

With pyridine; sulfur; tert-Amyl alcohol; sodium hydride; 3-Hydroxypropionitrile; In tetrahydrofuran;
DOI:10.1039/b316304k