1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

Base Information

Chemical Name:1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole
CAS No.:229153-08-6
Molecular Formula:C₁₄H₁₅F₄N₃OS
Molecular Weight:349.352
Hs Code.:

Synonyms:1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

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Chemical Property of 1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

Chemical Property:

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Technology Process of 1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

There total 6 articles about 1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 229153-04-2
2-(2,4-difluorophenyl)-1-(ethylthio)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanol

: 229153-08-6
1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

Guidance literature:: 2-(2,4-difluorophenyl)-1-(ethylthio)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanol; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h;

MeX; In dimethyl sulfoxide; at 20 ℃; for 15h;
DOI:10.1248/cpb.49.173

Reference yield:

: 229153-04-2
2-(2,4-difluorophenyl)-1-(ethylthio)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanol

: 74-88-4
methyl iodide

: 229153-08-6
1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

Guidance literature:: In water; N,N-dimethyl-formamide;

Reference yield:

: 102429-07-2
2-bromo-2',4'-difluoroacetophenone

: 229153-08-6
1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / dimethylsulfoxide / 15 h / 20 °C

2.1: 85 percent / N-fluoro-2,4,6-trimethylpyridinium triflate; zinc bromide / 1,1,2-trichloro-ethane / 80 - 105 °C

3.1: NaH / dimethylsulfoxide; tetrahydrofuran / 1 h / 20 °C

3.2: 90 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C

4.1: 85 percent / K₂CO₃ / dimethylformamide / 5 h / 65 °C

5.1: NaH / dimethylsulfoxide / 1 h / 20 °C

5.2: 68 percent / dimethylsulfoxide / 15 h / 20 °C

With sodium hydride; potassium carbonate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; zinc dibromide; In tetrahydrofuran; 1,1,2-trichloroethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.173