5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

Base Information

Chemical Name:5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one
CAS No.:1002757-01-8
Molecular Formula:C₁₅H₉F₃O₃S
Molecular Weight:326.296
Hs Code.:

Synonyms:5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

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Chemical Property of 5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

Chemical Property:

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Technology Process of 5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

There total 1 articles about 5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209991-63-9
2,4,6-trifluorophenylacetic acid

: 75815-46-2
2-bromo-1-thiophen-2-yl-propan-1-one

: 1002757-01-8
5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

Guidance literature:: 2,4,6-trifluorophenylacetic acid; 2-bromo-1-thiophen-2-yl-propan-1-one; With triethylamine; In acetonitrile; at 20 ℃; for 16h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 2.5h; Cooling;

With oxygen; In acetonitrile; for 3h;

Reference yield:

: 1002757-01-8
5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

: 6-methyl-5-thiophen-2-yl-4-(2,4,6-trifluorophenyl)-2H-pyridazin-3-one

Guidance literature:: With hydrazine; In butan-1-ol; at 120 ℃; for 16h;

Reference yield:

: 1002757-01-8
5-hydroxy-5-methyl-4-thiophen-2-yl-3-(2,4,6-trifluorophenyl)-5H-furan-2-one

: 3,6-dimethyl-4-thiophen-2-yl-5-(2,4,6-trifluorophenyl)-pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / butan-1-ol / 16 h / 120 °C

2: trichlorophosphate / 1 h / 110 °C

3: iron(III)-acetylacetonate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether / 3 h / -70 - 20 °C

With hydrazine; trichlorophosphate; iron(III)-acetylacetonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; butan-1-ol;